{"created":"2023-05-15T11:33:23.817419+00:00","id":3856,"links":{},"metadata":{"_buckets":{"deposit":"249f8a89-9ad1-49f6-89ea-4dfd5cbf6c94"},"_deposit":{"created_by":1,"id":"3856","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3856"},"status":"published"},"_oai":{"id":"oai:nsg.repo.nii.ac.jp:00003856","sets":["6:10:12:67"]},"author_link":["14140"],"item_19_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"53","bibliographicPageStart":"42","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Niigata journal of health and welfare"}]}]},"item_19_description_16":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_19_description_45":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_19_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Myocilin gene is directly linked to the most common form of glaucoma. The gene product is secreted into aqueous humor and is thought to be involved in the regulation of intraocular pressure. Most of the mutant myocilin proteins accumulate in cultured cells and are not secreted. In this study, through staining experiments of various cell lines, we demonstrated that secreted myocilin could bind to a particular cell surface to exert its function. Myocilin secreted by COS-1 cells was able to bind specifically to the surface of NIH3T3 cells. The binding of myocilin was dependent on the cell density. These results suggest that myocilin recognizes a specific cell and exerts its effect upon binding to the cell surface.","subitem_description_type":"Abstract"}]},"item_19_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata Society of Health and Welfare"}]},"item_19_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11614542","subitem_source_identifier_type":"NCID"}]},"item_19_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-8782","subitem_source_identifier_type":"ISSN"}]},"item_19_text_47":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_19_text_48":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_19_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Minami, Masayoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-30"}],"displaytype":"detail","filename":"042_053e0901.pdf","filesize":[{"value":"474.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"042_053e0901.pdf","url":"https://nsg.repo.nii.ac.jp/record/3856/files/042_053e0901.pdf"},"version_id":"8571d0bf-9312-47cf-86ea-82bec38ac639"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Myocilin","subitem_subject_scheme":"Other"},{"subitem_subject":"Glaucoma","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Myocilin from COS-1 cells binds specifically to NIH3T3 cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Myocilin from COS-1 cells binds specifically to NIH3T3 cells"}]},"item_type_id":"19","owner":"1","path":["67"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-05-25"},"publish_date":"2011-05-25","publish_status":"0","recid":"3856","relation_version_is_last":true,"title":["Myocilin from COS-1 cells binds specifically to NIH3T3 cells"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:00:41.703544+00:00"}