@article{oai:nsg.repo.nii.ac.jp:00005004,
 author = {Pham Van, Manh and Saito, Kei and Miyaguchi, Shota and Tsuiki, Shota and Onishi, Hideaki},
 issue = {2},
 journal = {Niigata journal of health and welfare, 1346-8782},
 month = {},
 note = {application/pdf, 論文(Article), Afferent input from peripheral nerves plays an important role in modulating corticospinal excitability. It is known that afferent input induced by paired-pulse electrical stimulation (ppES) with an interval between two doublets of 5 ms significantly increases corticospinal excitability, with short-duration ppES having a greater effect than single-pulse electrical stimulation (sES). In contrast, long-duration ppES was inefficient in modulating corticospinal excitability. It is possible that the stimulation frequency was effective in modulating the change in corticospinal excitability induced by long-duration ppES. The present study investigated the effect of long-duration (20min) ppES on the corticospinal excitability using transcranial magnetic stimulation (TMS). In Experiment 1, motor-evoked potentials (MEPs) were measured before and after (immediately, 5, 10, 15, and 20 min after) sES at 30 Hz (120% sensory threshold or 120% motor threshold) or ppES with an interval between two doublets of 5 ms (120% sensory threshold, 30 Hz). In Experiment 2, MEPs were measured before and after sES at 15 or 60 Hz (120% sensory threshold) or ppES at 15 or 60 Hz (120% sensory threshold, an interval between two doublets of 5 ms). In Experiment 3, MEPs were measured before and after ppES with an interval between two doublets of 10 or 15 ms (120% sensory threshold, 15 Hz). Application of ppES at 30 Hz with an interval between two doublets of 5 ms significantly increased MEP, as did sES at 120% motor threshold. Moreover, ppES at 15 and 60 Hz with an interval between two doublets of 5 ms significantly increased MEP, and ppES at 15 Hz with an interval between two doublets of 15 ms significantly decreased MEP. These results suggest that corticospinal excitability increased after ppES is induced by paired-pulse paradigm and not by the total number of pulses.},
 pages = {109--121},
 title = {Effects of long-duration paired-pulse electrical stimulation on excitability of the corticospinal tract in healthy subjects},
 volume = {19},
 year = {2019}
}