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Age at onset and the disturbance of orientation in Alzheimer's disease
https://nsg.repo.nii.ac.jp/records/3570
https://nsg.repo.nii.ac.jp/records/35704b4b5420-8c51-4f49-812d-2ae47bcb50e1
名前 / ファイル | ライセンス | アクション |
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KJ00004416777.pdf (434.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-03-05 | |||||
タイトル | ||||||
タイトル | Age at onset and the disturbance of orientation in Alzheimer's disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dementia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Presenile dementia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Senile dementia of Alzheimer type | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Onset age | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Disorientation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Imamura, Toru
× Imamura, Toru× Fujimori, Misato× Hirono, Nobutsugu× Hashimoto, Mamoru× Kazui, Hiroaki× Mori, Etsuro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A recent study of Alzheimer's disease (AD) showed a correlation between the disturbance of orientation for time and place and the hypometabolism in the posterior cingulate cortex. In another study of AD, patients with later age at onset have more severe reduction of regional glucose metabolism in the retrosplenial area. These two findings raise a hypothesis that late-onset AD patients have more severe disturbance of orientation than do early-onset patients. We examined the effect of age at onset on the disturbance of orientation using a large sample of mild-to-moderate AD and multivariate statistics controlling for confounding factors. The disturbances were assessed both by the subtest of the Alzheimer's Disease Assessment Scale (ADAS) as neuropsychological measure and by the subscale of the Clinical Dementia Rating (CDR) as clinical measure. The latethan early-onset patients performed significantly worse on the ADAS orientation subtest, and were rated significantly worse on the CDR orientation subscale. The current results confirmed the hypothesis. The clinical characteristic of lateonset patients present a contrast to those of earlyonset patients who are reported to show more profound disturbances of language, attention and visuocognitive functions. The differences between early- and late-onset patients suggest a heterogeneity of AD, and are important to increase the accuracy of early diagnosis and management. | |||||
書誌情報 |
Niigata journal of health and welfare 巻 5, 号 1, p. 60-64, 発行日 2005 |
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出版者 | ||||||
出版者 | Niigata Society of Health and Welfare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-8782 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11614542 | |||||
権利 | ||||||
権利情報 | 本文データは国立情報学研究所により電子化されたものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 論文(Article) | |||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text |